Desensitization of Ca2+-dependent intracellular alkalization by muscarinic stimulation with carbachol in smooth muscle.
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چکیده
منابع مشابه
Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle.
Contractile responses of airway smooth muscle (ASM) determine airway resistance in health and disease. Caveolae microdomains in the plasma membrane are marked by caveolin proteins and are abundant in contractile smooth muscle in association with nanospaces involved in Ca(2+) homeostasis. Caveolin-1 can modulate localization and activity of signaling proteins, including trimeric G proteins, via ...
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The effects of intracellular nucleotide triphosphates on time-dependent changes in muscarinic receptor cation currents (I(cat)) were investigated using the whole cell patch-clamp technique in guinea pig ileal muscle. In the absence of nucleotide phosphates in the patch pipette, I(cat) evoked every 10 min decayed progressively. This decay was slowed dose dependently by inclusion of millimolar co...
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It is important to clarify developmental mechanisms of desensitization because of their great significance in regulation of cellular responsiveness. We have found that carbachol-induced desensitization to carbachol develops in three successive phases in the presence of extracellular Ca(2+) in the smooth muscle of guinea pig taenia caeci: fast desensitization within 15 s, transient resensitizati...
متن کاملDesensitization of smooth muscle cells in the guinea pig taenia coli to prolonged application of carbachol.
depolarized the membrane, reduced the membrane resistance and evoked contracture. These responses did not, however, continue but a desensitization to Carb then developed, i. e. the membrane was gradually repolarized, membrane resistance increased, and the muscle relaxed in spite of the presence of Carb. 2. During the repolarization phase in the presence of Carb (10-5 g/ml), repeated current pul...
متن کاملZataria multiflora Boiss inhibits muscarinic receptors of incubated tracheal smooth muscle with propranolol
Objective(s): In the present study, the effect of tissue incubation with propranolol on functional antagonism of Zataria multiflora Boiss (Z. multiflora) at muscarinic receptors of tracheal smooth muscle was examined. Materials and Methods: The effects of three concentrations of aqueous-ethanolic extract, 10 nM atropine, and saline on muscarinic receptors were tested on incubated tracheal smoo...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1994
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)50847-2